Brendan Fraser gives a career-defining performance in Academy Award-nominated director Darren Aronofsky’s (Black Swan) arrestingly intimate drama about a reclusive English professor struggling with personal relationships and self-acceptance, adapted from the stage play by Samuel D. Hunter. Writing instructor Charlie (Fraser) never seems to have his webcam enabled while teaching online. He makes excuses and is so good-natured that no one makes a fuss, but the real reason for his invisibility is his appearance. Charlie weighs 600 pounds. His obesity starts to pose a grave threat to his health and his friend Liz (Hong Chau; The Menu, Driveways), a nurse, begs him to check into a hospital, but also recognizes that it might be more important to simply offer support. Charlie’s current status quo is upended by the return of his long-estranged adolescent daughter, Ellie (Sadie Sink; Stranger Things), though her willingness to resume a relationship seems prompted as much by Charlie’s offers to ghostwrite her school essays as it is by her sense of familial loyalty. Meanwhile, Charlie receives visits from a door-to-door evangelist (Ty Simpkins) who engages him in a dialogue about redemption that, despite Charlie’s lack of religious inclination, proves surprisingly resonant. Can any of these folks, regardless of their personal agendas, serve as the lifeline to self-acceptance that Charlie so urgently needs? The film’s six-minute standing ovation at its Venice International Film Festival World Premiere was a fitting recognition of the incredible performances from the stellar cast and Fraser, in particular, whose sincere portrayal is astonishing.